Pesquisa | Secretaria de Estado da Saúde

1.

Distinct baseline immune characteristics associated with responses to conjugated and unconjugated pneumococcal polysaccharide vaccines in older adults.

Ravichandran, Sathyabaarathi; Erra-Diaz, Fernando; Karakaslar, Onur E; Marches, Radu; Kenyon-Pesce, Lisa; Rossi, Robert; Chaussabel, Damien; Nehar-Belaid, Djamel; LaFon, David C; Pascual, Virginia; Palucka, Karolina; Paust, Silke; Nahm, Moon H; Kuchel, George A; Banchereau, Jacques; Ucar, Duygu.

Nat Immunol ; 25(2): 316-329, 2024 Feb.

Artigo Inglês | MEDLINE | ID: mdl-38182669

2.

Sestrins induce natural killer function in senescent-like CD8⁺ T cells.

Pereira, Branca I; De Maeyer, Roel P H; Covre, Luciana P; Nehar-Belaid, Djamel; Lanna, Alessio; Ward, Sophie; Marches, Radu; Chambers, Emma S; Gomes, Daniel C O; Riddell, Natalie E; Maini, Mala K; Teixeira, Vitor H; Janes, Samuel M; Gilroy, Derek W; Larbi, Anis; Mabbott, Neil A; Ucar, Duygu; Kuchel, George A; Henson, Sian M; Strid, Jessica; Lee, Jun H; Banchereau, Jacques; Akbar, Arne N.

Nat Immunol ; 21(6): 684-694, 2020 06.

Artigo Inglês | MEDLINE | ID: mdl-32231301

3.

Improving the Approach to Defining, Classifying, Reporting and Monitoring Adverse Events in Seriously Ill Older Adults: Recommendations from a Multi-stakeholder Convening.

Baim-Lance, Abigail; Ferreira, Katelyn B; Cohen, Harvey Jay; Ellenberg, Susan S; Kuchel, George A; Ritchie, Christine; Sachs, Greg A; Kitzman, Dalane; Morrison, R Sean; Siu, Albert.

J Gen Intern Med ; 38(2): 399-405, 2023 Feb.

Artigo Inglês | MEDLINE | ID: mdl-35581446

4.

Loss of resilience contributes to detrusor underactivity in advanced age.

Ramasamy, Ramalakshmi; Baker, Dylan S; Lemtiri-Chlieh, Fouad; Rosenberg, Dawn A; Woon, Eric; Al-Naggar, Iman M; Hardy, Cara C; Levine, Eric S; Kuchel, George A; Bartley, Jenna M; Smith, Phillip P.

Biogerontology ; 24(2): 163-181, 2023 04.

Artigo Inglês | MEDLINE | ID: mdl-36626035

5.

The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial.

Martin, Dominique E; Cadar, Andreia N; Panier, Hunter; Torrance, Blake L; Kuchel, George A; Bartley, Jenna M.

Immun Ageing ; 20(1): 18, 2023 May 02.

Artigo Inglês | MEDLINE | ID: mdl-37131271

6.

The hyperpolarization-activated, cyclic nucleotide-gated channel resides on myocytes in mouse bladders and contributes to adrenergic-induced detrusor relaxation.

Lemtiri-Chlieh, Fouad; Baker, Dylan S; Al-Naggar, Iman M; Ramasamy, Ramalakshmi; Kuchel, George A; Levine, Eric S; Robson, Paul; Smith, Phillip P.

Am J Physiol Regul Integr Comp Physiol ; 323(1): R110-R122, 2022 07 01.

Artigo Inglês | MEDLINE | ID: mdl-35503519

7.

Increased Levels of Circulating Cell-Free mtDNA in the Plasma of Subjects With Late-Life Depression and Frailty: A Preliminary Study.

Ampo, Emi; Mendes-Silva, Ana Paula; Goncalves, Vanessa; Bartley, Jenna M; Kuchel, George A; Diniz, Breno S.

Am J Geriatr Psychiatry ; 30(3): 332-337, 2022 03.

Artigo Inglês | MEDLINE | ID: mdl-34412934

8.

Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.

Diniz, Breno S; Lima-Costa, Maria Fernanda; Peixoto, Sérgio Viana; Firmo, Joselia O A; Torres, Karen C L; Martins-Filho, Olindo Assis; Teixeira-Carvalho, Andréa; Grady, James; Kuchel, George A; Castro-Costa, Erico.

Am J Geriatr Psychiatry ; 30(7): 825-833, 2022 07.

Artigo Inglês | MEDLINE | ID: mdl-35227616

9.

Alzheimer's disease amyloidogenesis is linked to altered lower urinary tract physiology.

Hardy, Cara C; Ramasamy, Ramalakshmi; Rosenberg, Dawn A; Kuchel, George A; Yan, Riqiang; Hu, Xiangyou; Smith, Phillip P.

Neurourol Urodyn ; 41(6): 1344-1354, 2022 08.

Artigo Inglês | MEDLINE | ID: mdl-35579273

10.

Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons.

Verschoor, Chris P; Belsky, Daniel W; Andrew, Melissa K; Haynes, Laura; Loeb, Mark; Pawelec, Graham; McElhaney, Janet E; Kuchel, George A.

Immun Ageing ; 19(1): 39, 2022 Aug 23.

Artigo Inglês | MEDLINE | ID: mdl-35999604

11.

Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells.

Picard, Emilie; Armstrong, Sarah; Andrew, Melissa K; Haynes, Laura; Loeb, Mark; Pawelec, Graham; Kuchel, George A; McElhaney, Janet E; Verschoor, Chris P.

Immun Ageing ; 19(1): 26, 2022 May 26.

Artigo Inglês | MEDLINE | ID: mdl-35619117

12.

The lethal sex gap: COVID-19.

Márquez, Eladio J; Trowbridge, Jennifer; Kuchel, George A; Banchereau, Jacques; Ucar, Duygu.

Immun Ageing ; 17: 13, 2020.

Artigo Inglês | MEDLINE | ID: mdl-32457811

13.

The immune response to influenza in older humans: beyond immune senescence.

McElhaney, Janet E; Verschoor, Chris P; Andrew, Melissa K; Haynes, Laura; Kuchel, George A; Pawelec, Graham.

Immun Ageing ; 17: 10, 2020.

Artigo Inglês | MEDLINE | ID: mdl-32399058

14.

Obesity and Longer Term Risks of Dementia in 65-74 Year Olds.

Bowman, Kirsty; Thambisetty, Madhav; Kuchel, George A; Ferrucci, Luigi; Melzer, David.

Age Ageing ; 48(3): 367-373, 2019 05 01.

Artigo Inglês | MEDLINE | ID: mdl-30726871

15.

Methodologic considerations in the design and analysis of nested case-control studies: association between cytokines and postoperative delirium.

Ngo, Long H; Inouye, Sharon K; Jones, Richard N; Travison, Thomas G; Libermann, Towia A; Dillon, Simon T; Kuchel, George A; Vasunilashorn, Sarinnapha M; Alsop, David C; Marcantonio, Edward R.

BMC Med Res Methodol ; 17(1): 88, 2017 Jun 06.

Artigo Inglês | MEDLINE | ID: mdl-28587598

16.

Oral glycotoxins are a modifiable cause of dementia and the metabolic syndrome in mice and humans.

Cai, Weijing; Uribarri, Jaime; Zhu, Li; Chen, Xue; Swamy, Shobha; Zhao, Zhengshan; Grosjean, Fabrizio; Simonaro, Calogera; Kuchel, George A; Schnaider-Beeri, Michal; Woodward, Mark; Striker, Gary E; Vlassara, Helen.

Proc Natl Acad Sci U S A ; 111(13): 4940-5, 2014 Apr 01.

Artigo Inglês | MEDLINE | ID: mdl-24567379

17.

Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12.

Ble, Alessandro; Masoli, Jane A H; Barry, Heather E; Winder, Rachel E; Tavakoly, Behrooz; Henley, William E; Kuchel, George A; Valderas, Jose M; Melzer, David; Richards, Suzanne H.

BMC Geriatr ; 15: 146, 2015 Nov 05.

Artigo Inglês | MEDLINE | ID: mdl-26542116

18.

International drive to illuminate delirium: A developing public health blueprint for action.

Khachaturian, Ara S; Hayden, Kathleen M; Devlin, John W; Fleisher, Lee A; Lock, Sarah Lenz; Cunningham, Colm; Oh, Esther S; Fong, Tamara G; Fick, Donna Marie; Marcantonio, Edward R; Iyengar, Vijeth; Rockwood, Kenneth; Kuchel, George A; Eckenhoff, Roderic G; MacLullich, Alasdair M J; Jones, Richard N; Davis, Daniel; D'Antonio, Patricia M; Fargo, Keith N; Albert, Marilyn S; Williamson, Jeff D; Ling, Shari M; Weiss, Joan; Karlawish, Jason; Petersen, Ronald C; Blazer, Dan G; Khachaturian, Zaven S; Inouye, Sharon K.

Alzheimers Dement ; 16(5): 711-725, 2020 05.

Artigo Inglês | MEDLINE | ID: mdl-32212231

19.

Editorial Comment.

Kuchel, George A.

J Urol ; 202(5): 1020-1021, 2019 11.

Artigo Inglês | MEDLINE | ID: mdl-31403897

20.

Recruitment and retention of healthy and high-risk older adults for a multiyear influenza vaccination study.

Dill, Joshua; Unson, Christine; Kenyon-Pesce, Lisa; Kuchel, George A; McElhaney, Janet.

Conn Med ; 78(8): 481-6, 2014 Sep.

Artigo Inglês | MEDLINE | ID: mdl-25314888

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